Drug interactions
Dasatinib + Osilodrostat
Severity: Moderate
Dasatinib and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Using them together may increase the risk of torsades de pointes, particularly in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Dasatinib and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation through effects on cardiac repolarisation.
What to do
Obtain an ECG at baseline and again after starting the combination, and keep potassium and magnesium in the normal range. Reduce the dose or stop one drug if the QTc rises substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Dasatinib with Osilodrostat?
MediHelp rates the interaction as moderate. Dasatinib and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Using them together may increase the risk of torsades de pointes, particularly in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Dasatinib and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and again after starting the combination, and keep potassium and magnesium in the normal range. Reduce the dose or stop one drug if the QTc rises substantially.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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