Drug interactions
Dasatinib + Osimertinib
Severity: Moderate
Dasatinib and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib and osimertinib each have the potential to prolong the QT interval. Combined use may raise the risk of ventricular arrhythmia, especially with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Dasatinib and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Osimertinib belongs to Oncology.
Why it happens
Additive QT prolongation through effects on cardiac repolarisation.
What to do
Perform periodic ECG monitoring and check electrolytes, correcting any potassium or magnesium deficit. Interrupt or reduce the dose of the offending agent if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Dasatinib with Osimertinib?
MediHelp rates the interaction as moderate. Dasatinib and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib and osimertinib each have the potential to prolong the QT interval. Combined use may raise the risk of ventricular arrhythmia, especially with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Dasatinib and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG monitoring and check electrolytes, correcting any potassium or magnesium deficit. Interrupt or reduce the dose of the offending agent if QTc becomes markedly prolonged.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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