Drug interactions
Dasatinib + Oxaliplatin
Severity: Major
Dasatinib and Oxaliplatin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib can prolong the QT interval, and oxaliplatin has been reported to do the same. Using them together may increase the likelihood of clinically significant arrhythmia, particularly with hypokalemia or hypomagnesemia from chemotherapy.
What this interaction means in plain words
Dasatinib and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Check ECG at baseline and during therapy, and keep potassium and magnesium within normal range. Consider alternatives if the QTc exceeds acceptable limits.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Oxaliplatin?
MediHelp rates the interaction as major. Dasatinib and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib can prolong the QT interval, and oxaliplatin has been reported to do the same. Using them together may increase the likelihood of clinically significant arrhythmia, particularly with hypokalemia or hypomagnesemia from chemotherapy.
How serious is the interaction between Dasatinib and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and during therapy, and keep potassium and magnesium within normal range. Consider alternatives if the QTc exceeds acceptable limits.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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