Drug interactions
Dasatinib + Ribociclib
Severity: Major
Dasatinib and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval and ribociclib is a CYP3A4 inhibitor that may increase dasatinib exposure. The combination increases the risk of arrhythmia and dasatinib toxicity.
What this interaction means in plain words
Dasatinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by ribociclib reducing dasatinib clearance.
What to do
Avoid if an alternative exists; if used, monitor ECG and electrolytes and watch for dasatinib adverse effects such as myelosuppression and fluid retention.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Dasatinib with Ribociclib?
MediHelp rates the interaction as major. Dasatinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents prolong the QT interval and ribociclib is a CYP3A4 inhibitor that may increase dasatinib exposure. The combination increases the risk of arrhythmia and dasatinib toxicity.
How serious is the interaction between Dasatinib and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists; if used, monitor ECG and electrolytes and watch for dasatinib adverse effects such as myelosuppression and fluid retention.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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