Drug interactions
Dasatinib + Rilpivirine
Severity: Moderate
Dasatinib and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib can prolong the QT interval, and rilpivirine at supratherapeutic doses has also been associated with QT prolongation. Together they may add to the risk of arrhythmia.
What this interaction means in plain words
Dasatinib and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Rilpivirine belongs to Anti Virals.
Why it happens
Additive effects on cardiac repolarisation.
What to do
Obtain a baseline ECG and keep potassium and magnesium within normal limits. Repeat the ECG if other QT-prolonging drugs are added or symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Dasatinib with Rilpivirine?
MediHelp rates the interaction as moderate. Dasatinib and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib can prolong the QT interval, and rilpivirine at supratherapeutic doses has also been associated with QT prolongation. Together they may add to the risk of arrhythmia.
How serious is the interaction between Dasatinib and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and keep potassium and magnesium within normal limits. Repeat the ECG if other QT-prolonging drugs are added or symptoms develop.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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