Drug interactions
Dasatinib + Solifenacin
Severity: Moderate
Dasatinib and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and may modestly raise solifenacin exposure. Both drugs can prolong the QT interval, so the combination may increase arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Dasatinib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Weak CYP3A4 inhibition by dasatinib plus additive QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and anticholinergic effects, and limit the solifenacin dose if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Solifenacin?
MediHelp rates the interaction as moderate. Dasatinib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a weak CYP3A4 inhibitor and may modestly raise solifenacin exposure. Both drugs can prolong the QT interval, so the combination may increase arrhythmia risk, especially with other risk factors.
How serious is the interaction between Dasatinib and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and anticholinergic effects, and limit the solifenacin dose if QT risk is high.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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