Drug interactions
Dasatinib + Tacrolimus
Severity: Moderate
Dasatinib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak-to-moderate CYP3A4 inhibitor and may raise tacrolimus exposure, which has a narrow therapeutic range. Both drugs can also prolong the QT interval, so toxicity such as nephrotoxicity, neurotoxicity or arrhythmia is more likely.
What this interaction means in plain words
Dasatinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Dasatinib inhibits CYP3A4-mediated tacrolimus metabolism, and both drugs have additive QT-prolonging effects.
What to do
Monitor tacrolimus trough concentrations and renal function when starting or stopping dasatinib, adjusting the tacrolimus dose as needed. Obtain a baseline ECG and monitor QTc and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Dasatinib with Tacrolimus?
MediHelp rates the interaction as moderate. Dasatinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a weak-to-moderate CYP3A4 inhibitor and may raise tacrolimus exposure, which has a narrow therapeutic range. Both drugs can also prolong the QT interval, so toxicity such as nephrotoxicity, neurotoxicity or arrhythmia is more likely.
How serious is the interaction between Dasatinib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function when starting or stopping dasatinib, adjusting the tacrolimus dose as needed. Obtain a baseline ECG and monitor QTc and electrolytes.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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