Drug interactions
Dasatinib + Trastuzumab deruxtecan
Severity: Moderate
Dasatinib and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, and trastuzumab deruxtecan commonly causes neutropenia. Combined use may increase the risk of severe neutropenia and infection.
What this interaction means in plain words
Dasatinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive bone marrow suppression.
What to do
Monitor complete blood counts regularly and educate patients about fever and infection. Delay doses or reduce them per labeling if severe neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Dasatinib with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Dasatinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, and trastuzumab deruxtecan commonly causes neutropenia. Combined use may increase the risk of severe neutropenia and infection.
How serious is the interaction between Dasatinib and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and educate patients about fever and infection. Delay doses or reduce them per labeling if severe neutropenia develops.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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