Drug interactions
Dasatinib + Vorinostat
Severity: Moderate
Dasatinib and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT prolongation. Their combination may increase the risk of ventricular arrhythmias, especially with electrolyte abnormalities.
What this interaction means in plain words
Dasatinib and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Vorinostat belongs to Oncology.
Why it happens
Additive QT prolongation through effects on cardiac repolarisation.
What to do
Perform ECG and electrolyte monitoring, correcting potassium and magnesium. Interrupt therapy or adjust doses if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Dasatinib with Vorinostat?
MediHelp rates the interaction as moderate. Dasatinib and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT prolongation. Their combination may increase the risk of ventricular arrhythmias, especially with electrolyte abnormalities.
How serious is the interaction between Dasatinib and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG and electrolyte monitoring, correcting potassium and magnesium. Interrupt therapy or adjust doses if QTc becomes markedly prolonged.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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