Drug interactions
Daunorubicin + Ranolazine
Severity: Minor
Daunorubicin and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein, which could raise daunorubicin exposure. Clinical significance is uncertain, but increased myelosuppression or cardiotoxicity is theoretically possible.
What this interaction means in plain words
Daunorubicin and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daunorubicin belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition by ranolazine may reduce daunorubicin efflux and clearance.
What to do
Monitor blood counts and cardiac function as routinely done during daunorubicin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Frequently asked questions
Can I take Daunorubicin with Ranolazine?
MediHelp rates the interaction as minor. Daunorubicin and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine inhibits P-glycoprotein, which could raise daunorubicin exposure. Clinical significance is uncertain, but increased myelosuppression or cardiotoxicity is theoretically possible.
How serious is the interaction between Daunorubicin and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function as routinely done during daunorubicin therapy.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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