Drug interactions
Daunorubicin + Stiripentol
Severity: Minor
Daunorubicin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein and BCRP, transporters involved in anthracycline efflux. Exposure to daunorubicin may increase, potentially worsening myelosuppression and cardiotoxicity.
What this interaction means in plain words
Daunorubicin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daunorubicin belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of P-gp and BCRP efflux transporters by stiripentol may reduce daunorubicin clearance.
What to do
Monitor blood counts and cardiac status. Consider reducing the daunorubicin dose if adverse reactions develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Daunorubicin with Stiripentol?
MediHelp rates the interaction as minor. Daunorubicin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-glycoprotein and BCRP, transporters involved in anthracycline efflux. Exposure to daunorubicin may increase, potentially worsening myelosuppression and cardiotoxicity.
How serious is the interaction between Daunorubicin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status. Consider reducing the daunorubicin dose if adverse reactions develop.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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