Drug interactions
Daunorubicin + Tucatinib
Severity: Moderate
Daunorubicin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and may increase daunorubicin exposure, raising the risk of myelosuppression and cardiotoxicity. Both drugs can also affect cardiac or hepatic function.
What this interaction means in plain words
Daunorubicin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-gp efflux of daunorubicin.
What to do
Monitor blood counts and cardiac function; consider reducing daunorubicin dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Daunorubicin with Tucatinib?
MediHelp rates the interaction as moderate. Daunorubicin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-glycoprotein and may increase daunorubicin exposure, raising the risk of myelosuppression and cardiotoxicity. Both drugs can also affect cardiac or hepatic function.
How serious is the interaction between Daunorubicin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function; consider reducing daunorubicin dose if toxicity occurs.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporin. The full list is on the Daunorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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