Drug interactions
Defibrotide + Diclofenac
Severity: Moderate
Defibrotide and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity and may increase the bleeding risk when given with drugs that affect hemostasis, such as NSAIDs. Diclofenac adds antiplatelet effect and gastrointestinal bleeding risk.
What this interaction means in plain words
Defibrotide and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect on hemostasis; defibrotide promotes fibrinolysis while diclofenac inhibits platelet function.
What to do
Avoid NSAIDs where possible in patients receiving defibrotide, who are often thrombocytopenic. If used, monitor for signs of bleeding and platelet counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Diclofenac?
MediHelp rates the interaction as moderate. Defibrotide and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity and may increase the bleeding risk when given with drugs that affect hemostasis, such as NSAIDs. Diclofenac adds antiplatelet effect and gastrointestinal bleeding risk.
How serious is the interaction between Defibrotide and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible in patients receiving defibrotide, who are often thrombocytopenic. If used, monitor for signs of bleeding and platelet counts.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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