Drug interactions
Defibrotide + Etodolac
Severity: Moderate
Defibrotide and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity, so combining it with an NSAID that impairs platelet function may increase bleeding risk. Defibrotide labeling advises against concomitant use with systemic anticoagulants or fibrinolytics, and antiplatelet drugs warrant caution.
What this interaction means in plain words
Defibrotide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effects on hemostasis from profibrinolytic activity and NSAID platelet inhibition.
What to do
Monitor for bleeding and consider withholding etodolac during defibrotide therapy, using paracetamol for analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Etodolac?
MediHelp rates the interaction as moderate. Defibrotide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity, so combining it with an NSAID that impairs platelet function may increase bleeding risk. Defibrotide labeling advises against concomitant use with systemic anticoagulants or fibrinolytics, and antiplatelet drugs warrant caution.
How serious is the interaction between Defibrotide and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider withholding etodolac during defibrotide therapy, using paracetamol for analgesia.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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