Drug interactions
Defibrotide + Fluoxetine
Severity: Moderate
Defibrotide and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity, and fluoxetine impairs platelet function, so combined use may increase bleeding. Defibrotide is generally not recommended with other agents that affect hemostasis.
What this interaction means in plain words
Defibrotide and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive hemostatic effects of defibrotide and SSRI-induced platelet dysfunction.
What to do
Monitor for bleeding and review the need for fluoxetine during defibrotide treatment. Hold either agent if significant bleeding develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Fluoxetine?
MediHelp rates the interaction as moderate. Defibrotide and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity, and fluoxetine impairs platelet function, so combined use may increase bleeding. Defibrotide is generally not recommended with other agents that affect hemostasis.
How serious is the interaction between Defibrotide and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and review the need for fluoxetine during defibrotide treatment. Hold either agent if significant bleeding develops.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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