Drug interactions
Defibrotide + Indomethacin
Severity: Moderate
Defibrotide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity, and combining it with an antiplatelet NSAID such as indomethacin may increase the risk of hemorrhage. Defibrotide labeling advises against concurrent use with systemic anticoagulants or fibrinolytics, and caution is needed with other agents affecting hemostasis.
What this interaction means in plain words
Defibrotide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
Additive effects on hemostasis from defibrotide's profibrinolytic action and NSAID platelet inhibition.
What to do
Monitor for bleeding and consider withholding indomethacin during defibrotide therapy. Prefer a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Indomethacin?
MediHelp rates the interaction as moderate. Defibrotide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity, and combining it with an antiplatelet NSAID such as indomethacin may increase the risk of hemorrhage. Defibrotide labeling advises against concurrent use with systemic anticoagulants or fibrinolytics, and caution is needed with other agents affecting hemostasis.
How serious is the interaction between Defibrotide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider withholding indomethacin during defibrotide therapy. Prefer a non-NSAID analgesic.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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