Drug interactions
Defibrotide + Oxaprozin
Severity: Moderate
Defibrotide and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity and may increase bleeding risk with drugs affecting hemostasis. NSAIDs impair platelet function and can add to this risk.
What this interaction means in plain words
Defibrotide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effects on hemostasis from defibrotide's fibrinolytic activity and oxaprozin's platelet inhibition.
What to do
Monitor for bleeding and platelet and coagulation parameters, and avoid NSAIDs where an alternative analgesic is possible. Follow defibrotide labeling regarding concomitant antithrombotic agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Oxaprozin?
MediHelp rates the interaction as moderate. Defibrotide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity and may increase bleeding risk with drugs affecting hemostasis. NSAIDs impair platelet function and can add to this risk.
How serious is the interaction between Defibrotide and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and platelet and coagulation parameters, and avoid NSAIDs where an alternative analgesic is possible. Follow defibrotide labeling regarding concomitant antithrombotic agents.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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