Drug interactions
Defibrotide + Sertraline
Severity: Moderate
Defibrotide and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic activity and can increase bleeding risk. SSRIs such as sertraline impair platelet function, so combining them may further raise the likelihood of hemorrhage.
What this interaction means in plain words
Defibrotide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Additive effects on hemostasis: defibrotide enhances fibrinolysis while sertraline depletes platelet serotonin and reduces platelet aggregation.
What to do
Monitor for signs of bleeding and check platelet counts and coagulation parameters as clinically indicated. Reassess the need for the SSRI if significant bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Sertraline?
MediHelp rates the interaction as moderate. Defibrotide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic activity and can increase bleeding risk. SSRIs such as sertraline impair platelet function, so combining them may further raise the likelihood of hemorrhage.
How serious is the interaction between Defibrotide and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check platelet counts and coagulation parameters as clinically indicated. Reassess the need for the SSRI if significant bleeding occurs.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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