Drug interactions
Deflazacort + Enzalutamide
Severity: Major
Deflazacort and Enzalutamide: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort's active metabolite is formed and cleared via CYP3A4, and strong inducers markedly reduce its exposure. Efficacy of deflazacort may be lost.
What this interaction means in plain words
Deflazacort and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deflazacort belongs to Miscellaneous; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, lowering exposure to the active metabolite of deflazacort.
What to do
Avoid concomitant use, as labeling advises against moderate or strong CYP3A4 inducers with deflazacort. Consider an alternative corticosteroid or alternative to enzalutamide.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Enzalutamide?
MediHelp rates the interaction as major. Deflazacort and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deflazacort's active metabolite is formed and cleared via CYP3A4, and strong inducers markedly reduce its exposure. Efficacy of deflazacort may be lost.
How serious is the interaction between Deflazacort and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use, as labeling advises against moderate or strong CYP3A4 inducers with deflazacort. Consider an alternative corticosteroid or alternative to enzalutamide.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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