Drug interactions
Deflazacort + Human papillomavirus vaccine
Severity: Minor
Deflazacort and Human papillomavirus vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids at higher doses can reduce antibody responses to non-live vaccines such as HPV vaccine. The vaccine is safe but may be less effective.
What this interaction means in plain words
Deflazacort and Human papillomavirus vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Human papillomavirus vaccine belongs to Miscellaneous.
Why it happens
Glucocorticoid-mediated suppression of lymphocyte function reduces vaccine immunogenicity.
What to do
Vaccinate on schedule, ideally before starting prolonged high-dose therapy; do not delay vaccination for non-live vaccines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Human papillomavirus vaccine?
MediHelp rates the interaction as minor. Deflazacort and Human papillomavirus vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic corticosteroids at higher doses can reduce antibody responses to non-live vaccines such as HPV vaccine. The vaccine is safe but may be less effective.
How serious is the interaction between Deflazacort and Human papillomavirus vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate on schedule, ideally before starting prolonged high-dose therapy; do not delay vaccination for non-live vaccines.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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