Drug interactions
Degarelix + Posaconazole
Severity: Moderate
Degarelix and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Degarelix, as androgen deprivation therapy, may prolong the QT interval, and posaconazole also prolongs QT. Combined use may increase the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Degarelix and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before and during therapy. Monitor the QTc periodically, especially in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Posaconazole?
MediHelp rates the interaction as moderate. Degarelix and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Degarelix, as androgen deprivation therapy, may prolong the QT interval, and posaconazole also prolongs QT. Combined use may increase the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
How serious is the interaction between Degarelix and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before and during therapy. Monitor the QTc periodically, especially in patients with other risk factors.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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