Drug interactions
Mitomycin + Trastuzumab deruxtecan
Severity: Major
Mitomycin and Trastuzumab deruxtecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause myelosuppression, and trastuzumab deruxtecan also causes neutropenia and interstitial lung disease. Combined use may increase the risk of neutropenia, infection and pulmonary toxicity, since mitomycin can also cause lung injury.
What this interaction means in plain words
Mitomycin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitomycin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive bone marrow suppression and overlapping pulmonary toxicity.
What to do
Monitor complete blood counts frequently and assess for new respiratory symptoms. Interrupt or reduce doses for significant neutropenia and stop trastuzumab deruxtecan if interstitial lung disease is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Mitomycin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Mitomycin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can cause myelosuppression, and trastuzumab deruxtecan also causes neutropenia and interstitial lung disease. Combined use may increase the risk of neutropenia, infection and pulmonary toxicity, since mitomycin can also cause lung injury.
How serious is the interaction between Mitomycin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and assess for new respiratory symptoms. Interrupt or reduce doses for significant neutropenia and stop trastuzumab deruxtecan if interstitial lung disease is suspected.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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