Drug interactions
Denosumab + Gemcitabine
Severity: Moderate
Denosumab and Gemcitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab labeling advises caution in patients with impaired immunity or those taking immunosuppressants because serious infections, including skin infections, have been reported. Gemcitabine causes myelosuppression, so combined use may add to infection risk in oncology patients.
What this interaction means in plain words
Denosumab and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Gemcitabine belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: denosumab inhibits RANKL signalling in immune cells while gemcitabine suppresses bone marrow function.
What to do
Monitor for signs of infection and check blood counts per chemotherapy protocol. Treat infections promptly and counsel the patient to report fever or skin changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Denosumab and Gemcitabine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Gemcitabine
Frequently asked questions
Can I take Denosumab with Gemcitabine?
MediHelp rates the interaction as moderate. Denosumab and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab labeling advises caution in patients with impaired immunity or those taking immunosuppressants because serious infections, including skin infections, have been reported. Gemcitabine causes myelosuppression, so combined use may add to infection risk in oncology patients.
How serious is the interaction between Denosumab and Gemcitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts per chemotherapy protocol. Treat infections promptly and counsel the patient to report fever or skin changes.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
