Drug interactions
Denosumab + Hydroxycarbamide
Severity: Moderate
Denosumab and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyurea is myelosuppressive and denosumab has been associated with serious infections, so the combination may raise infection risk. The clinical impact is mainly theoretical and extrapolated from labeling.
What this interaction means in plain words
Denosumab and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: RANKL inhibition by denosumab plus hydroxyurea-induced bone marrow suppression.
What to do
Monitor blood counts and clinically for infection. Evaluate fever promptly and treat infections early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Denosumab with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Denosumab and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyurea is myelosuppressive and denosumab has been associated with serious infections, so the combination may raise infection risk. The clinical impact is mainly theoretical and extrapolated from labeling.
How serious is the interaction between Denosumab and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and clinically for infection. Evaluate fever promptly and treat infections early.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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