Drug interactions
Denosumab + Rilonacept
Severity: Moderate
Denosumab and Rilonacept: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks interleukin-1 and may increase susceptibility to infection. Denosumab labeling cautions about serious infections in patients with impaired immunity, so the risk may be additive.
What this interaction means in plain words
Denosumab and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Rilonacept belongs to Miscellaneous.
Why it happens
Additive infection risk from IL-1 blockade and possible immune effects of RANKL inhibition.
What to do
Monitor for signs of infection and hold rilonacept during active serious infection. Counsel patients to report fever early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Rilonacept
Frequently asked questions
Can I take Denosumab with Rilonacept?
MediHelp rates the interaction as moderate. Denosumab and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilonacept blocks interleukin-1 and may increase susceptibility to infection. Denosumab labeling cautions about serious infections in patients with impaired immunity, so the risk may be additive.
How serious is the interaction between Denosumab and Rilonacept?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and hold rilonacept during active serious infection. Counsel patients to report fever early.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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