Drug interactions
Denosumab + Tacrolimus
Severity: Moderate
Denosumab and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is a calcineurin inhibitor that suppresses immunity, and denosumab has been linked to serious infections. Combined use may increase infection risk in transplant patients.
What this interaction means in plain words
Denosumab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effect: calcineurin inhibition of T-cell activation plus RANKL inhibition affecting immune cells.
What to do
Monitor for infection, including opportunistic and skin infections, and treat promptly. Reassess ongoing need for denosumab against infection risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Denosumab with Tacrolimus?
MediHelp rates the interaction as moderate. Denosumab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus is a calcineurin inhibitor that suppresses immunity, and denosumab has been linked to serious infections. Combined use may increase infection risk in transplant patients.
How serious is the interaction between Denosumab and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection, including opportunistic and skin infections, and treat promptly. Reassess ongoing need for denosumab against infection risk.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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