Drug interactions
Denosumab + Trastuzumab deruxtecan
Severity: Moderate
Denosumab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan causes neutropenia and can cause interstitial lung disease, both of which raise infection and respiratory risk. Denosumab labeling warns of serious infections in immunocompromised patients, so the risks may add together.
What this interaction means in plain words
Denosumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive infection risk from antibody-drug conjugate myelosuppression and possible immune effects of denosumab.
What to do
Monitor neutrophil counts and respiratory symptoms. Evaluate fever or new cough promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Denosumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Denosumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan causes neutropenia and can cause interstitial lung disease, both of which raise infection and respiratory risk. Denosumab labeling warns of serious infections in immunocompromised patients, so the risks may add together.
How serious is the interaction between Denosumab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and respiratory symptoms. Evaluate fever or new cough promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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