Drug interactions
Desflurane + Dexchlorpheniramine
Severity: Minor
Desflurane and Dexchlorpheniramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine, and desflurane is a CNS depressant. Combined use may increase drowsiness and slow recovery, with added anticholinergic effects.
What this interaction means in plain words
Desflurane and Dexchlorpheniramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desflurane belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression through H1 receptor antagonism and general anesthetic action.
What to do
Titrate desflurane to effect and observe for prolonged sedation postoperatively. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desflurane
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Desflurane with Dexchlorpheniramine?
MediHelp rates the interaction as minor. Desflurane and Dexchlorpheniramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexchlorpheniramine is a sedating antihistamine, and desflurane is a CNS depressant. Combined use may increase drowsiness and slow recovery, with added anticholinergic effects.
How serious is the interaction between Desflurane and Dexchlorpheniramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate desflurane to effect and observe for prolonged sedation postoperatively. No dose change is usually needed.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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