Drug interactions
Desflurane + Difelikefalin
Severity: Minor
Desflurane and Difelikefalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin is a peripherally restricted kappa-opioid agonist that can cause dizziness and somnolence. With desflurane there may be a small increase in sedation, although its limited central penetration makes a large effect unlikely.
What this interaction means in plain words
Desflurane and Difelikefalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desflurane belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Possible additive CNS depression; difelikefalin has limited central penetration.
What to do
Titrate desflurane to clinical effect and monitor postoperative sedation. No dose adjustment is routinely required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desflurane
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Desflurane with Difelikefalin?
MediHelp rates the interaction as minor. Desflurane and Difelikefalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin is a peripherally restricted kappa-opioid agonist that can cause dizziness and somnolence. With desflurane there may be a small increase in sedation, although its limited central penetration makes a large effect unlikely.
How serious is the interaction between Desflurane and Difelikefalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate desflurane to clinical effect and monitor postoperative sedation. No dose adjustment is routinely required.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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