Drug interactions
Desflurane + Eliglustat
Severity: Moderate
Desflurane and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can increase ECG intervals at high plasma concentrations, and volatile anesthetics can prolong QT as well. Together they may add to the risk of arrhythmia.
What this interaction means in plain words
Desflurane and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Additive effects on cardiac repolarization; the interaction is predicted from the individual QT effects.
What to do
Check baseline QTc and electrolytes before anesthesia and monitor the ECG perioperatively. Be aware of CYP2D6 phenotype and CYP inhibitors that raise eliglustat exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Desflurane with Eliglustat?
MediHelp rates the interaction as moderate. Desflurane and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can increase ECG intervals at high plasma concentrations, and volatile anesthetics can prolong QT as well. Together they may add to the risk of arrhythmia.
How serious is the interaction between Desflurane and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and electrolytes before anesthesia and monitor the ECG perioperatively. Be aware of CYP2D6 phenotype and CYP inhibitors that raise eliglustat exposure.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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