Drug interactions
Desflurane + Esmolol
Severity: Moderate
Desflurane and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane depress myocardial contractility and cause vasodilation, and esmolol adds to these effects. Hypotension and bradycardia may be exaggerated during anesthesia.
What this interaction means in plain words
Desflurane and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Esmolol belongs to Cardiovascular.
Why it happens
Additive negative inotropic and hypotensive effects of anesthetic-induced vasodilation and myocardial depression with beta-blockade.
What to do
Titrate esmolol carefully under continuous hemodynamic monitoring and adjust anesthetic depth or esmolol dose to maintain blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Esmolol?
MediHelp rates the interaction as moderate. Desflurane and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane depress myocardial contractility and cause vasodilation, and esmolol adds to these effects. Hypotension and bradycardia may be exaggerated during anesthesia.
How serious is the interaction between Desflurane and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate esmolol carefully under continuous hemodynamic monitoring and adjust anesthetic depth or esmolol dose to maintain blood pressure.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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