Drug interactions
Desflurane + Fluphenazine
Severity: Moderate
Desflurane and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines add to the CNS depression and hypotension seen with volatile anesthetics. Both drug classes can prolong the QT interval, so arrhythmia risk is increased during anesthesia.
What this interaction means in plain words
Desflurane and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression, vasodilation and alpha-adrenergic blockade, and additive QT prolongation.
What to do
Inform the anesthesia team of fluphenazine use before surgery and review the baseline ECG and electrolytes. Titrate the anesthetic carefully and monitor blood pressure and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Fluphenazine?
MediHelp rates the interaction as moderate. Desflurane and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines add to the CNS depression and hypotension seen with volatile anesthetics. Both drug classes can prolong the QT interval, so arrhythmia risk is increased during anesthesia.
How serious is the interaction between Desflurane and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of fluphenazine use before surgery and review the baseline ECG and electrolytes. Titrate the anesthetic carefully and monitor blood pressure and ECG.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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