Drug interactions
Desflurane + Fluvoxamine
Severity: Minor
Desflurane and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane can prolong the QT interval, and an SSRI could add a small additional effect. The clinical significance appears limited, as fluvoxamine has low intrinsic QT liability, and the evidence is largely theoretical.
What this interaction means in plain words
Desflurane and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desflurane belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation; no well-established interaction mechanism.
What to do
Inform the anesthesia team of the fluvoxamine use and monitor ECG intraoperatively, ensuring normal potassium and magnesium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Fluvoxamine?
MediHelp rates the interaction as minor. Desflurane and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Volatile anesthetics such as desflurane can prolong the QT interval, and an SSRI could add a small additional effect. The clinical significance appears limited, as fluvoxamine has low intrinsic QT liability, and the evidence is largely theoretical.
How serious is the interaction between Desflurane and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of the fluvoxamine use and monitor ECG intraoperatively, ensuring normal potassium and magnesium.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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