Drug interactions
Desflurane + Gilteritinib
Severity: Major
Desflurane and Gilteritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib can prolong the QT interval, and desflurane can add to this effect. Together they raise the risk of torsades de pointes, especially with electrolyte disturbance.
What this interaction means in plain words
Desflurane and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desflurane belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Check baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG continuously and consider propofol-based anesthesia if QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desflurane
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Desflurane with Gilteritinib?
MediHelp rates the interaction as major. Desflurane and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib can prolong the QT interval, and desflurane can add to this effect. Together they raise the risk of torsades de pointes, especially with electrolyte disturbance.
How serious is the interaction between Desflurane and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG continuously and consider propofol-based anesthesia if QTc is prolonged.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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