Drug interactions
Desflurane + Hydroxyzine
Severity: Moderate
Desflurane and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is associated with QT prolongation and torsades de pointes, and desflurane may add to the effect. It also adds sedation and anticholinergic effects around the time of anesthesia.
What this interaction means in plain words
Desflurane and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive QT prolongation, with additive CNS depression.
What to do
Check ECG and electrolytes in patients with other QT risk factors, and monitor the ECG during anesthesia. Avoid hydroxyzine premedication in patients with long QT or on other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Desflurane with Hydroxyzine?
MediHelp rates the interaction as moderate. Desflurane and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is associated with QT prolongation and torsades de pointes, and desflurane may add to the effect. It also adds sedation and anticholinergic effects around the time of anesthesia.
How serious is the interaction between Desflurane and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with other QT risk factors, and monitor the ECG during anesthesia. Avoid hydroxyzine premedication in patients with long QT or on other QT-prolonging drugs.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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