Drug interactions
Desflurane + Iloperidone
Severity: Moderate
Desflurane and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval, and desflurane can add to this effect. The combination increases the risk of torsades de pointes.
What this interaction means in plain words
Desflurane and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively and consider an alternative anesthetic if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Desflurane with Iloperidone?
MediHelp rates the interaction as moderate. Desflurane and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone prolongs the QT interval, and desflurane can add to this effect. The combination increases the risk of torsades de pointes.
How serious is the interaction between Desflurane and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively and consider an alternative anesthetic if QTc is prolonged.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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