Drug interactions
Desflurane + Itraconazole
Severity: Moderate
Desflurane and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are associated with QT prolongation, so combining them during anesthesia could add to arrhythmia risk. The clinical evidence is limited.
What this interaction means in plain words
Desflurane and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check the baseline QTc and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Itraconazole?
MediHelp rates the interaction as moderate. Desflurane and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are associated with QT prolongation, so combining them during anesthesia could add to arrhythmia risk. The clinical evidence is limited.
How serious is the interaction between Desflurane and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline QTc and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia in patients with other QT risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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