Drug interactions
Desflurane + Lasmiditan
Severity: Moderate
Desflurane and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence, and its use with other CNS depressants has not been formally studied. With desflurane it may increase sedation and delay psychomotor recovery.
What this interaction means in plain words
Desflurane and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; lasmiditan is a 5-HT1F agonist with sedative properties.
What to do
Avoid giving lasmiditan on the day of anesthesia where possible and monitor recovery of alertness. Advise patients not to drive for at least 8 hours after a dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Desflurane with Lasmiditan?
MediHelp rates the interaction as moderate. Desflurane and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence, and its use with other CNS depressants has not been formally studied. With desflurane it may increase sedation and delay psychomotor recovery.
How serious is the interaction between Desflurane and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving lasmiditan on the day of anesthesia where possible and monitor recovery of alertness. Advise patients not to drive for at least 8 hours after a dose.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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