Drug interactions
Desflurane + Macimorelin
Severity: Moderate
Desflurane and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so concurrent exposure may raise the risk of ventricular arrhythmia. Macimorelin is given as a single diagnostic dose, so overlap with anesthesia is short and avoidable.
What this interaction means in plain words
Desflurane and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Do not perform the macimorelin stimulation test around the time of general anesthesia; schedule it separately. If both are unavoidable, monitor ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Macimorelin
Frequently asked questions
Can I take Desflurane with Macimorelin?
MediHelp rates the interaction as moderate. Desflurane and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so concurrent exposure may raise the risk of ventricular arrhythmia. Macimorelin is given as a single diagnostic dose, so overlap with anesthesia is short and avoidable.
How serious is the interaction between Desflurane and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not perform the macimorelin stimulation test around the time of general anesthesia; schedule it separately. If both are unavoidable, monitor ECG.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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