Drug interactions
Desflurane + Mefloquine
Severity: Moderate
Desflurane and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane can prolong the QT interval, and mefloquine may add to this effect during the perioperative period. The risk of arrhythmia is greater with electrolyte disturbances.
What this interaction means in plain words
Desflurane and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Inform the anesthesia team of recent mefloquine use and review the preoperative ECG. Correct electrolytes and monitor the ECG continuously during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Mefloquine?
MediHelp rates the interaction as moderate. Desflurane and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane can prolong the QT interval, and mefloquine may add to this effect during the perioperative period. The risk of arrhythmia is greater with electrolyte disturbances.
How serious is the interaction between Desflurane and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent mefloquine use and review the preoperative ECG. Correct electrolytes and monitor the ECG continuously during anesthesia.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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