Drug interactions
Desflurane + Metoprolol
Severity: Moderate
Desflurane and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desflurane causes vasodilation and can produce sympathetic activation at high concentrations, while metoprolol blunts compensatory responses. Hypotension and bradycardia may be more pronounced during anesthesia.
What this interaction means in plain words
Desflurane and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Metoprolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic cardiovascular depression from volatile anesthetic effects and beta-1 blockade.
What to do
Inform the anesthesia team and monitor blood pressure and heart rate throughout. Usually continue chronic beta-blockers perioperatively and treat hypotension promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Metoprolol?
MediHelp rates the interaction as moderate. Desflurane and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desflurane causes vasodilation and can produce sympathetic activation at high concentrations, while metoprolol blunts compensatory responses. Hypotension and bradycardia may be more pronounced during anesthesia.
How serious is the interaction between Desflurane and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and monitor blood pressure and heart rate throughout. Usually continue chronic beta-blockers perioperatively and treat hypotension promptly.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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