Drug interactions
Desflurane + Moxifloxacin
Severity: Moderate
Desflurane and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane can prolong the QT interval, and moxifloxacin adds to this effect perioperatively. The combination may increase the risk of arrhythmia during anesthesia.
What this interaction means in plain words
Desflurane and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization leading to QT prolongation.
What to do
Inform the anesthesia team and monitor ECG intraoperatively. Ensure potassium and magnesium are normal before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Moxifloxacin?
MediHelp rates the interaction as moderate. Desflurane and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane can prolong the QT interval, and moxifloxacin adds to this effect perioperatively. The combination may increase the risk of arrhythmia during anesthesia.
How serious is the interaction between Desflurane and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and monitor ECG intraoperatively. Ensure potassium and magnesium are normal before surgery.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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