Drug interactions
Desflurane + Nabilone
Severity: Moderate
Desflurane and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desflurane is a general inhalational anaesthetic, and nabilone has central depressant effects that may add to anaesthetic depth and postoperative sedation. It may also contribute to cardiovascular effects such as tachycardia and blood pressure changes during anaesthesia.
What this interaction means in plain words
Desflurane and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Inform the anaesthesia team of recent nabilone use and titrate anaesthetic dose to effect with hemodynamic monitoring. Observe for prolonged postoperative sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Nabilone?
MediHelp rates the interaction as moderate. Desflurane and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desflurane is a general inhalational anaesthetic, and nabilone has central depressant effects that may add to anaesthetic depth and postoperative sedation. It may also contribute to cardiovascular effects such as tachycardia and blood pressure changes during anaesthesia.
How serious is the interaction between Desflurane and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anaesthesia team of recent nabilone use and titrate anaesthetic dose to effect with hemodynamic monitoring. Observe for prolonged postoperative sedation.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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