Drug interactions
Desflurane + Osilodrostat
Severity: Moderate
Desflurane and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and volatile anesthetics such as desflurane may also lengthen it. The combination may raise the risk of arrhythmia, especially with hypokalemia, which osilodrostat can also cause.
What this interaction means in plain words
Desflurane and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive QTc prolongation, with osilodrostat-related hypokalemia as a further contributor.
What to do
Check ECG, potassium and magnesium before anesthesia and correct abnormalities. Monitor the ECG during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Osilodrostat
Frequently asked questions
Can I take Desflurane with Osilodrostat?
MediHelp rates the interaction as moderate. Desflurane and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and volatile anesthetics such as desflurane may also lengthen it. The combination may raise the risk of arrhythmia, especially with hypokalemia, which osilodrostat can also cause.
How serious is the interaction between Desflurane and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG, potassium and magnesium before anesthesia and correct abnormalities. Monitor the ECG during and after the procedure.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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