Drug interactions
Desflurane + Oxaliplatin
Severity: Moderate
Desflurane and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation, and desflurane may add to the effect. Oxaliplatin-related electrolyte losses such as hypokalemia and hypomagnesemia can further raise arrhythmia risk.
What this interaction means in plain words
Desflurane and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG, potassium and magnesium before surgery and correct deficits. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Desflurane with Oxaliplatin?
MediHelp rates the interaction as moderate. Desflurane and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation, and desflurane may add to the effect. Oxaliplatin-related electrolyte losses such as hypokalemia and hypomagnesemia can further raise arrhythmia risk.
How serious is the interaction between Desflurane and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG, potassium and magnesium before surgery and correct deficits. Monitor the ECG during anesthesia.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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