Drug interactions
Desflurane + Perphenazine
Severity: Moderate
Desflurane and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
General anesthetics add to the CNS depressant and hypotensive effects of phenothiazines, and both can prolong the QT interval. Patients taking perphenazine may have deeper or prolonged sedation and hemodynamic instability during anesthesia.
What this interaction means in plain words
Desflurane and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression, vasodilation and QT prolongation.
What to do
Inform the anesthesia team about perphenazine use and monitor ECG, blood pressure and depth of anesthesia. Correct electrolyte abnormalities before the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Perphenazine?
MediHelp rates the interaction as moderate. Desflurane and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. General anesthetics add to the CNS depressant and hypotensive effects of phenothiazines, and both can prolong the QT interval. Patients taking perphenazine may have deeper or prolonged sedation and hemodynamic instability during anesthesia.
How serious is the interaction between Desflurane and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about perphenazine use and monitor ECG, blood pressure and depth of anesthesia. Correct electrolyte abnormalities before the procedure.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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