Drug interactions
Desflurane + Phentermine
Severity: Moderate
Desflurane and Phentermine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine increases sympathetic tone, and desflurane can cause sympathetic activation and myocardial sensitization. The combination may cause hypertension, tachycardia or ventricular arrhythmias during anesthesia.
What this interaction means in plain words
Desflurane and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Phentermine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic stimulation combined with anesthetic-related catecholamine sensitization.
What to do
Inform the anesthesia team and consider holding phentermine before elective surgery. Monitor blood pressure and ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Desflurane with Phentermine?
MediHelp rates the interaction as moderate. Desflurane and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentermine increases sympathetic tone, and desflurane can cause sympathetic activation and myocardial sensitization. The combination may cause hypertension, tachycardia or ventricular arrhythmias during anesthesia.
How serious is the interaction between Desflurane and Phentermine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and consider holding phentermine before elective surgery. Monitor blood pressure and ECG during anesthesia.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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