Drug interactions
Desflurane + Ribociclib
Severity: Major
Desflurane and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes dose-dependent QT prolongation and volatile anesthetics may add to this effect. The combination can increase the risk of torsades de pointes, especially with electrolyte abnormalities.
What this interaction means in plain words
Desflurane and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desflurane belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Review the baseline QTc and correct potassium and magnesium before surgery. Monitor the ECG throughout anesthesia, and consider an alternative anesthetic or temporary interruption of ribociclib if the QTc is markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desflurane
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Desflurane with Ribociclib?
MediHelp rates the interaction as major. Desflurane and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib causes dose-dependent QT prolongation and volatile anesthetics may add to this effect. The combination can increase the risk of torsades de pointes, especially with electrolyte abnormalities.
How serious is the interaction between Desflurane and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the baseline QTc and correct potassium and magnesium before surgery. Monitor the ECG throughout anesthesia, and consider an alternative anesthetic or temporary interruption of ribociclib if the QTc is markedly prolonged.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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