Drug interactions
Desflurane + Rilpivirine
Severity: Minor
Desflurane and Rilpivirine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval, and volatile anesthetics can also lengthen it. At standard doses the added risk is small but may matter with other risk factors.
What this interaction means in plain words
Desflurane and Rilpivirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desflurane belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check electrolytes and baseline ECG in patients with other QT risk factors. Monitor the ECG perioperatively.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desflurane
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Desflurane with Rilpivirine?
MediHelp rates the interaction as minor. Desflurane and Rilpivirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rilpivirine at supratherapeutic doses prolongs the QT interval, and volatile anesthetics can also lengthen it. At standard doses the added risk is small but may matter with other risk factors.
How serious is the interaction between Desflurane and Rilpivirine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes and baseline ECG in patients with other QT risk factors. Monitor the ECG perioperatively.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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