Drug interactions
Desflurane + Solifenacin
Severity: Minor
Desflurane and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane can prolong the QT interval and solifenacin may add a small further effect. The risk matters mainly in patients with congenital long QT, electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Desflurane and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desflurane belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Review the preoperative ECG in at-risk patients and correct potassium and magnesium. Continuing solifenacin perioperatively is usually acceptable with routine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Solifenacin?
MediHelp rates the interaction as minor. Desflurane and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Volatile anesthetics such as desflurane can prolong the QT interval and solifenacin may add a small further effect. The risk matters mainly in patients with congenital long QT, electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Desflurane and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG in at-risk patients and correct potassium and magnesium. Continuing solifenacin perioperatively is usually acceptable with routine monitoring.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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